| 红霉素A9-肟羟基的醚化保护 |
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| 引用本文： | 梁建华,邓志华,孙京国,林美娜,姚国伟. 红霉素A9-肟羟基的醚化保护[J]. 北京理工大学学报, 2003, 23(1): 120-122 |
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| 作者姓名： | 梁建华 邓志华 孙京国 林美娜 姚国伟 |
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| 作者单位： | 北京理工大学,生命科学与技术学院,北京,100081 |
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| 基金项目： | 国家经贸委技术创新项目;01BK-009; |
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| 摘 要： | 用3种烷氧基环己烯（1-异丙氧基环己烯，1-乙氧基环己烯和1-甲氧基环己烯）对红霉素肟的羟基加以保护，同时与醚化剂2-乙氧基丙烯作了比较，反应在二氯甲烷中进行，盐酸吡啶作催化剂，实验发现，1-异丙氧基环己烯和1-乙氧基环已烯的保护比较完全，并对后者进行了工艺研究。
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| 关 键 词： | 红霉素A9－肟 羟基 保护 克拉霉素 醚化剂 合成 大环内酯抗生素 烷氧基环己烯 2－乙氧基丙烯 |
| 文章编号： | 1001-0645(2003)01-0120-03 |
| 收稿时间： | 2002-04-26 |
Etherification Protection for Hydroxyls in Erythromycin A Oximes |
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| LIANG Jian-hu,DENG Zhi-hu,SUN Jing-guo,LIN Mei-na and YAO Guo-wei. Etherification Protection for Hydroxyls in Erythromycin A Oximes[J]. Journal of Beijing Institute of Technology(Natural Science Edition), 2003, 23(1): 120-122 |
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| Authors: | LIANG Jian-hu DENG Zhi-hu SUN Jing-guo LIN Mei-na YAO Guo-wei |
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| Affiliation: | School of Life Science and Technology, Beijing Institute of Technology, Beijing100081, China;School of Life Science and Technology, Beijing Institute of Technology, Beijing100081, China;School of Life Science and Technology, Beijing Institute of Technology, Beijing100081, China;School of Life Science and Technology, Beijing Institute of Technology, Beijing100081, China;School of Life Science and Technology, Beijing Institute of Technology, Beijing100081, China |
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| Abstract: | Three kinds of alkyloxy cyclohexene, viz. 1-isopropoxycyclohexene, 1-ethoxycyclohexene and 1-methoxycyclohexene, were investigated for hydroxyl protection in erythromycin oxime. The obtained results showed that 1-isopropoxycyclohexene and 1-ethoxycyclohexene were potential protective reagents in clarithromycin synthesis. |
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| Keywords: | clarithromycin erythromycin etherification synthesis |
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