| 大豆黄酮对衰老小鼠脑组织神经递质含量的调节 |
| |
| 引用本文： | 才金玲,单群,陆军,郑元林. 大豆黄酮对衰老小鼠脑组织神经递质含量的调节[J]. 天津科技大学学报, 2011, 26(6): 16-19 |
| |
| 作者姓名： | 才金玲 单群 陆军 郑元林 |
| |
| 作者单位： | 1. 天津市海洋资源与化学重点实验室,天津科技大学海洋科学与工程学院,天津300457
2. 徐州师范大学生命科学学院,徐州,221116 |
| |
| 基金项目： | 天津市海洋资源与化学重点实验室开放基金课题，天津科技大学引进人才科研启动基金 |
| |
| 摘 要： | 研究大豆黄酮对D–半乳糖致衰老小鼠脑神经递质水平的调节.连续背部注射D–半乳糖6周,建立衰老模型,然后灌胃大豆黄酮5周(实验组Ⅰ、Ⅱ的剂量分别为5、10 mg/(kg.d)),监测不同脑区乙酰胆碱、乙酰胆碱酯酶、多巴胺和5–羟色胺含量变化,探讨大豆黄酮对衰老小鼠脑组织神经递质水平的影响.结果表明,灌胃衰老小鼠大豆黄酮后,大脑皮质和海马中乙酰胆碱、乙酰胆碱酯酶、多巴胺和5–羟色胺含量明显上升,并且具有一定的剂量效应.说明大豆黄酮可以改善衰老小鼠脑组织中神经递质含量,具有明显的抗衰老作用.
|
| 关 键 词： | 大豆黄酮 抗衰老 乙酰胆碱 乙酰胆碱酯酶 多巴胺 5–羟色胺 |
Regulation of Daidzein on Neurotransmitter Levels in Brain of Aged Mice |
| |
| CAI Jin-ling,SHAN Qun,LU Jun,ZHENG Yuan-lin. Regulation of Daidzein on Neurotransmitter Levels in Brain of Aged Mice[J]. Journal of Tianjin University of Science & Technology, 2011, 26(6): 16-19 |
| |
| Authors: | CAI Jin-ling SHAN Qun LU Jun ZHENG Yuan-lin |
| |
| Affiliation: | CAI Jin-ling1,SHAN Qun2,LU Jun2,ZHENG Yuan-lin2(1.Tianjin Key Laboratory of Marine Resources and Chemistry,College of Marine Science and Engineering,Tianjin University of Science & Technology,Tianjin 300457,China,2.School of Life Science,Xuzhou Normal University,Xuzhou 221116,China) |
| |
| Abstract: | To observe daidzein on the effects of D-galactose induced senescence in mice,D-galactose was injected in the dorsal of mice for 6 weeks as an aged model.The aged mice were fed daidzein with the doses 5 mg/(kg.d)(Test Ⅰ)and 10 mg/(kg.d)(Test Ⅱ)for 5 weeks.The levels of acetylcholine,acetylcholinesterase,dopamine,and 5-hydroxytryptamine in brain of the aged mice were examined.The results showed that daidzein could increase acetylcholinea,cetylcholinesterase,dopamine,and 5-hydroxytryptamine levels in cortex and hippocampus of aged mice.Daidzein could increase neurotransmit-ter levels of the mice’s brain and have antisenecence in some degree. |
| |
| Keywords: | daidzein antisenescence acetylcholine acetylcholinesterase dopamine 5-hydroxytryptamine |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
