| 甘氨酸葡萄糖络铜(Ⅱ)的合成,表征及对O-2·和DNA的作用 |
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| 引用本文： | 刘小琴,乐芝凤,张香才.甘氨酸葡萄糖络铜(Ⅱ)的合成,表征及对O-2·和DNA的作用[J].三峡大学学报(自然科学版),2003,25(6):571-573. |
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| 作者姓名： | 刘小琴 乐芝凤 张香才 |
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| 作者单位： | 1. 三峡大学,医学院,湖北,宜昌,443003
2. 华中师范大学,化学系,武汉,430070 |
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| 摘 要： | 合成了二甘氨酸葡萄糖络铜(Ⅱ),并进行了组成及结构研究.采用比色法和荧光法研究该化 合物对超氧阴离子自由基和DNA的作用.结果表明:二甘氨酸葡萄糖络铜(Ⅱ)配合物能显著抑制 超氧阴离子自由基的生成,并能与DNA有效的结合.
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| 关 键 词： | 合成 氨基酸葡萄糖铜(Ⅱ)配合物 O2~-· DNA |
| 文章编号： | 1007-7081(2003)06-0571-03 |
| 修稿时间： | 2002年12月16 |
Synthesis and Characterization of Glycine-Glucose with Copper (Ⅱ)complex and Its Effect on O-2·and DNA |
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| Liu Xiaoqin Le Zhifen Zhang Xiangcai.Synthesis and Characterization of Glycine-Glucose with Copper (Ⅱ)complex and Its Effect on O-2·and DNA[J].Journal of China Three Gorges University(Natural Sciences),2003,25(6):571-573. |
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| Authors: | Liu Xiaoqin Le Zhifen Zhang Xiangcai |
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| Abstract: | The synthesis of glycine and D-glucose with copper (II)complex has been studied. This compound is characterized by elemental analysis, IR,US-Vis and ESR. Effect of the Cu-Gly2-Glu on O_2-.and DNA has been tested. The results show that the Cu-Gly2-Glu could inhibit the synthesis of O_-. markedly and could also combine with the salmon sperm DNA. |
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| Keywords: | synthesis complex of amino acid and D-Glucose with copper (II) superoxide anion radical DNA |
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