高尿酸血症及尿酸性肾病动物模型的建立及应用

为建立高尿酸血症及尿酸性肾病动物模型 ,以不同剂量腺嘌呤分别饲喂大鼠 ,并设别嘌呤醇作为治疗组 ,监测血尿酸、尿尿酸及肾功能变化 ,并进行肾组织病理形态学及超微结构观察。结果示中剂量组大鼠于实验第三天血尿酸水平升高 ,可持续一周。第十天出现肾功能损害 ,并可见间质性肾炎改变。别嘌呤醇组改变不明显。中剂量组大鼠可作为观察药物预防作用的高尿酸血症及尿酸性肾病动物模型

Establishment of Animal Model of Hyteruricenia and Hyperuricemic Nephropathy

? For establishing the animal model of hyteruricemia and hyperuricemic nephropathy,We fed rats with different doses of adenine,and set up the protective group with allopurinol.Blood uric acid,urine uric acid,function of the kidney,pathological morphology of the kidney were also observed. It shcwed that the blood uric acid level of “the middle dose group”began rising at the third day and continued for one week.The damage of the kidney's function occurred after ten days,and the interstitial nephritis could be found.The change of allopurinol's group was not obvious. According to it,it was obvious that “Middle dose group”was a kind of a animal model of hyperuricemia for observing protective effect of a medicine.The “Middle dose group”was also a kind of animal model of hyperuricemia nephropathy.