| 桑黄粗多糖对肿瘤细胞增殖及转移相关能力的抑制作用 |
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| 引用本文： | 赵澜,张红锋.桑黄粗多糖对肿瘤细胞增殖及转移相关能力的抑制作用[J].华东师范大学学报(自然科学版),2008,2008(2):78-84. |
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| 作者姓名： | 赵澜 张红锋 |
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| 作者单位： | 华东师范大学,生命科学学院,上海,200062 |
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| 摘 要： | 研究了桑黄粗多糖（PL）对高转移卵巢癌细胞（HO-8910PM）和乳腺癌细胞（Bcap-37）增殖和转移相关能力的影响及其作用的机制.研究结果表明,桑黄粗多糖能有效抑制裸鼠移植瘤的生长，抑制率为65.37%；对离体培养的HO-8910PM和Bcap-37细胞的抑制率分别达到15.53%和23.81%；500 ind/ml PL作用于HO-8910PM细胞96 h可诱导其凋亡，通过细胞周期G0/G1期阻滞而抑制细胞增殖和诱导细胞凋亡；PL能显著抑制HO-8910PM的黏附、侵袭和迁移等肿瘤转移相关能力.桑黄粗多糖具有抑制肿瘤细胞增殖及肿瘤转移的作用.
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| 关 键 词： | 桑黄多糖 高转移卵巢癌细胞 乳腺癌细胞 增殖 转移 桑黄多糖 高转移卵巢癌细胞 乳腺癌细胞 增殖 转移 |
| 文章编号： | 1000-5641(2008)02-0078-07 |
| 收稿时间： | 2007-3-1 |
| 修稿时间： | 2007年3月1日 |
Inhibitory effects of polysaccharides extracted from phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37(Chinese) |
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| ZHAO Lan,ZHANG Hong-feng.Inhibitory effects of polysaccharides extracted from phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37(Chinese)[J].Journal of East China Normal University(Natural Science),2008,2008(2):78-84. |
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| Authors: | ZHAO Lan ZHANG Hong-feng |
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| Institution: | School of Life Science, East China Normal University, Shanghai200062, China |
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| Abstract: | This paper studied the effects and mechanism of polysaccharides extracted from Phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37.The results showed PL inhibited the growth of Bcap37 tumor in vivo by 65.37%, while inhibited the proliferation of HO-8910PM and Bcap-37 in vitro respectively by 15.53% and 23.81%.PL induced G0/G1 phase arrest and 500 ind/ml PL induced HO-8910PM cell apoptosis after 96 h treatments.PL may act as a direct inhibitor of HO-8910PM cell adhesion, invasion and migration which are related to tumor metastasis.The result indicated that PL has inhibitory effect on tumor cell proliferation and metastasis. |
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