The effects of diltiazem onPeriplaneta americana |
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| Authors: | K R Jennings R W Steele A N Starratt |
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| Institution: | (1) Research Centre, Agriculture Canada, University Sub. P.O., N6A 5B7 London, Ontario, Canada;(2) Present address: Insecticide Discovery Dept., American Cyanamid Co., P.O. Box 400, 08540 Princeton, N.J., USA |
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| Abstract: | Summary The effects of the calcium antagonist diltiazem on nerve and muscle in the cockroachPeriplaneta americana were examined. Diltiazem was observed to inhibit myogenic and glutamate-induced contractions of the visceral muscle while having either a potentiating, an inhibiting or a biphasic effect against proctolin-induced contractions. Against the isolated nervous system, diltiazem induced an increase in spontaneous discharge activity, followed by nerve block. Injection of diltiazem into cockroaches produced behavioral and toxic effects.Acknowledgments. The expert technical assistance of Miss Susan Auffarth is gratefully acknowledged. Bioresmethrin was provided by Dr. G.J.P. Singh. We would like to thank Nordic Laboratories for the gift of diltiazem. |
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