云南怒族八种红细胞血型抗原调查分析

目的 :了解云南怒族ABO、Rh、MN、P、GPC、GPA、KeLL、Wrb血型系统抗原分布情况 ,为解决临床输血及人类学、遗传学、分子生物学提供理论依据。方法 :在怒族自然村采用随机抽样调查128人 ,进行血清学检测定型的方法。结果 :云南怒族ABO血型系统中表现型A>O>B>AB ;基因频率r>p>q。Rh血型系统中Rh( -D)阴性率占4 69 % ,d基因频率为0 2165 ,分布较高于我国各民族(除新疆维吾尔族外) ,该民族表现型CCDee居多 ,占31 25% ,其分布特征为CCDee>CcDee>CcDE>ccDE>ccdee>ccDee。MN血型系统中表现型M>MN>N ;基因频率m>n,该系统中的Mur抗原阳性率特别高为22 65%(29/128) ,与上海汉族阳性率为0 66%(6/900)相比 ,怒族Mur抗原分布明显高于汉族Mur抗原。P血型系统中基因频率P2(0 7552)>P1(0 2448) ;GPC、GPA、KeLL、Wrb血型皆为阳性。结论 :不同民族的血型抗原存在一定的差异性 ,怒族的血型分布有自己的特点。

Survey and Analysis of Four Group Antigens on Red Blood Cell on Nu Ethnic

Objective:To study the distribution of blood antigen system on red blood cells,including type ABO,Rh,MN and so on,in Nu ethnic group in Yunnan of China to provide a theory basis of transfusion,anthropology,genetics and molecular biology.Methods:128people were investigated randomly in a Nu ethnic village.The antigens on the red blood cells were detected by the serology methods.Results:The results showed that the most common antigen in the ABO system was type A,then rank subsequence was type O,B,and AB.The frequency of r gene was higher than that of p and q gene.The Rh negative rate was4.69%and the frequency of d gene was0.2165.Its distribution was the highest in the peoples in China,except for Xinjiang's.The most common phenotype in the people was CCDec(31.25%),namely CCDec>CcDec>CcDE>ccDE>ccdee>ccDee.In the MN system,the frequency of phenotype was as follow:M>MN>N,and the gene frequency of m was higher than that of n.The positive rate of Mur antigen was22.65%(29/128)and higher than that in Han people(0.66%,6/900)in Shanghai.The gene frequency of P2(0.7552)in P system was higher than that of P1(0.2448).GPC,GPA,KeLL and Wrb antigens were positive.Conclusions:The blood antigens were different in many ethnic groups,and the distribution of blood group in Nu ethnic group has some characteristics.