Similarities between sodium channels in excitable membranes and in epithelia |
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| Authors: | A W Cuthbert |
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| Institution: | (1) Department of Pharmacology, University of Cambridge, Hills Road, CB2 2QD Cambridge, (England) |
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| Abstract: | Summary The inhibitory effects of the pyrazine derivative, amiloride, on sodium transport in an amphibian epithelium has been studied as a function of pH. It is concluded that the charged (guanidinium) group interacts with a negatively charged acid grouping in the membrane. Similarities between sodium channels in excitable membranes and epithelia are highlighted. |
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