| 含环丙烷氨基酸残基的构象限制二肽的合成及其晶体结构研究 |
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| 引用本文： | 张刘生,潘成学,李丽,苏桂发,黄婉云,覃江克,唐煌. 含环丙烷氨基酸残基的构象限制二肽的合成及其晶体结构研究[J]. 广西师范大学学报(自然科学版), 2011, 29(3): 37-42 |
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| 作者姓名： | 张刘生 潘成学 李丽 苏桂发 黄婉云 覃江克 唐煌 |
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| 作者单位： | 1. 广西师范大学药用资源化学与药物分子工程国家重点实验室培育基地,广西桂林541004;广西师范大学化学化工学院,广西桂林541004
2. 桂林师范高等专科学校化学与工程技术系,广西桂林,541001 |
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| 基金项目： | 国家自然科学基金资助项目(20862003); 广西自然科学基金创新团队资助项目(2010GXNSFF013001) |
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| 摘 要： | 以(L)-苯丙氨酸甲酯盐酸盐、N-叔丁氧羰基-(L)-丙氨酸和2,3-二苯基-1-叔丁氧酰氨基环丙烷酸甲酯为原料,采用混酐法合成了两个含2,3-二苯基取代环丙烷氨基酸残基的构象限制二肽,并用IR、NMR、MS和单晶X-射线衍射对这两个二肽的结构进行了研究.
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| 关 键 词： | 构象限制二肽 混酐法 合成 晶体结构 |
Synthesis and Crystal Structure of Conformationally Constrained Dipeptide with 1-Aminocyclopropanecarboxylic Acid Residue |
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| ZHANG Liu-sheng,PAN Cheng-xue,LI Li,SU Gui-fa,HUANG Wan-yun,QIN Jiang-ke,TANG Huang. Synthesis and Crystal Structure of Conformationally Constrained Dipeptide with 1-Aminocyclopropanecarboxylic Acid Residue[J]. Journal of Guangxi Normal University(Natural Science Edition), 2011, 29(3): 37-42 |
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| Authors: | ZHANG Liu-sheng PAN Cheng-xue LI Li SU Gui-fa HUANG Wan-yun QIN Jiang-ke TANG Huang |
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| Affiliation: | ZHANG Liu-sheng1,2,PAN Cheng-xue1,LI Li1,SU Gui-fa1,HUANG Wan-yun3,QIN Jiang-ke1,TANG Huang1,2(1.State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources,Guangxi Normal University,Guilin Guangxi 541004,China,2.College of Chemistry and Chemical Engineering,3.Department of Chemistry and Chemical Engineering,Guilin Normal College,Guilin Guangxi 541001,China) |
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| Abstract: | Two conformationally constrained dipeptides with a trans-2,3-diaryl-1-aminocyclo-propanecarboxylic acid residue were synthesized from boc-(L)-phenylalanine,boc-(L)-alanine and 2,3-diphenyl-1-tert-butyl-cyclopropane carboxylic acid amide with the mixed anhydride methodology.The structures of two target compounds were studied by means of X-ray single crystal diffraction analysis. |
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| Keywords: | conformationally constrained dipeptide mixed anhydride methodology synthesis crystal structure |
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