| 11-氰基十一酸的甲酯化研究 |
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| 引用本文： | 肖攀,李林.11-氰基十一酸的甲酯化研究[J].湖南文理学院学报(自然科学版),2010,22(3):31-34. |
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| 作者姓名： | 肖攀 李林 |
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| 作者单位： | 湖南文理学院,化学化工学院,湖南,常德,415000;湖南文理学院,生命科学学院,湖南,常德,415000 |
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| 基金项目： | 湖南文理学院青年启动项目 |
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| 摘 要： | 11-氰基十一酸甲酯(MCU)可由11-氰基十一酸(CUA)与甲醇酯化合成.CUA的氰基酯化时易水解,需选择合适的催化剂并控制好酯化条件.通过实验确定98% H2SO4是酯化反应合适的催化剂(兼具吸水作用).用正交试验考察酯化条件,优化条件为:将0.03 mol的CUA和3.0g硅胶(吸水剂)加入到0.225 mol甲醇与0.015 mol的浓H2SO4混合液中,回流3 h,反应的产品收率可达65.8%,酸醇比对收率影响最大.合成产物用正己烷结晶精制后经质谱测得其相对分子量为225,红外光谱、质谱、核磁共振(1HNMR及13CNMR)结构表征证明酯化产物确为MCU;其熔点27.3～28.4 ℃,40℃时折光率1.440 3.
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| 关 键 词： | 11-氰基十一酸 甲酯化 催化 正交试验 表征 |
Study on the methy1 esterification of 11-cyanoundecanoic acid |
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| XIAO Pan,LI Lin.Study on the methy1 esterification of 11-cyanoundecanoic acid[J].Journal of Hunan University of Arts and Science:Natural Science Edition,2010,22(3):31-34. |
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| Authors: | XIAO Pan LI Lin |
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| Institution: | XIAO Pan1,LI Lin2(1.Chemistry Department,Hunan University of Arts and Science,Changde 415000,China,2.College of Life Science,China) |
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| Abstract: | Methy1 11-cyanoundecanoate(MCU) can be synthesized by methyl esterifying 11-cyanoundecanoic acid(CUA) with methanol in the presence of catalyst.During the esterification process,to choose a kind of catalyst and control the synthesis conditions to prevent the cyanogens group attached to CUA from being hydrolyzed is very important.On the basis of experiments,98% H2SO4 was selected as the suitable catalyst(also as water absorbent) to catalyze this reaction.The optimized methylation parameters were obtained thr... |
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| Keywords: | 11-cyanoundecanoic acid methyl esterification catalysis orthogonal test characterization |
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