Immunomodulation by recombinant human interleukin-8 and its signal transduction pathways in invertebrate hemocytes |
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Authors: | Ottaviani E Franchini A Malagoli D Genedani S |
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Institution: | Department of Animal Biology, University of Modena and Reggio Emilia, Italy. ottaviani.enzo@unimo.it |
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Abstract: | We report the presence of interleukin (IL)-8-immunoreactive molecules in hemocytes from the mollusc Mytilus galloprovincialis. Functional studies demonstrate that recombinant human (rh)IL-8 provokes conformational changes, induces chemotaxis, and increases bacterial phagocytic activity in hemocytes. rhIL-8 induces cell shape changes via protein kinase A and C pathways. These morphological changes are followed by reorganization of the actin microfilaments. The findings suggest that, as previously reported for other cytokines, IL-8 is well conserved and deeply involved in immune functions from invertebrates to mammals. |
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