| 丙二酸与光活性脂环酮的成环反应研究 |
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| 引用本文： | 曹国安,郑建辉.丙二酸与光活性脂环酮的成环反应研究[J].汕头大学学报(自然科学版),1995,10(2):72-76. |
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| 作者姓名： | 曹国安 郑建辉 |
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| 作者单位： | 汕头大学化学系，香港大学化学系 |
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| 摘 要： | 在乙酸酐和少量硫酸存在下，丙二酸与具光学活性脂环酮反应缩合成Ｍｅｌｄｒｕｍ酸的类似物．除（－）－薄荷酮生成相应产物产率可达３２％外，（Ｒ）－（十）－樟脑、（Ｓ）－（－）－樟脑和（Ｒ）－葑酮的反应产率仅有１～２％．（Ｒ）－诺蒎酮在这反应条件下发生重排反应，生成丙二酸（４’－亚异两基）亚环己酯，产率为３３％．
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| 关 键 词： | 丙二酸 脂环酮 缩合成环反应 |
Studies on the cyclization reaction between malonic acid and optically active aliphatic cyclic ketones |
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| Cao Guoan.Studies on the cyclization reaction between malonic acid and optically active aliphatic cyclic ketones[J].Journal of Shantou University(Natural Science Edition),1995,10(2):72-76. |
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| Authors: | Cao Guoan |
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| Abstract: | In the presence of acetic anhydride and a small amount of sulphuric acid, the condensation reaction between malonic acid and optically active aliphatic cyclic ketones gave Meldrum'S acid analogues. (-)-Menthone changed to its corresponding product in 32% yield, while (R) - ( ) -camphor (S) - (-)-camphor and (R)-fenchone turned to their corresponding products only in 1- 2% yield. In the same reaction condition,(R)-Nopinone rearranged into (4'-isopropylidene ) cyclohexylidene malonate in 33%yield. |
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| Keywords: | malonic acid cyclic ketone condensation reaction |
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