Evidence of a direct action of triiodothyronine (T3) on the cell membrane of GH3 cells: an electrophysiological approach |
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| Authors: | J S du Pont J -M Israel |
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| Institution: | (1) Biologisch Centrum Gebouw 11, University of Amsterdam, Dept. of Zoology, Kruislaan 320, NL-1098 SM Amsterdam, (The Netherlands);(2) I.N.S.E.R.M. U. 176, Neurobiologie des compartements, Domaine de Carreire, Rue Camille Saint-Saens, F-33076 Bordeaux Cedex, (France) |
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| Abstract: | Summary Electrophysiological experiments demonstrate that triiodothyronine (T3) exerts a direct effect on the membrane of a strain of cultured rat pituitary tumor cells, GH3/B6. These cells respond to pressure application of T3 (2–5 nl, concentration 1·10–10 M) with an increase in the membrane resistance (Rm) and a hyperpolarization. Spontaneously firing cells become silent. |
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| Keywords: | Triiodothyronine GH3 cells membrane potential membrane resistance action potentials |
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