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D-Aspartate oxidase activity and D-aspartate content in a mutant mouse strain lacking D-amino acid oxidase |
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| Authors: | H Nagasaki R Yamada R Konno Y Yasumura A Iwashima |
| Institution: | (1) Department of Biochemistry, Kyoto Prefectural University of Medicine, 602 Kyoto, (Japan);(2) Department of Microbiology, Dokkyo University School of Medicine, 321-02 Mibu, Tochigi, (Japan);(3) Present address: Department of Bioengineering, Nagaoka University of Technology, 940-21 Nagaoka, Niigata, (Japan) |
| Abstract: | Summary A mutant mouse strain ddY/DAO– lacks D-amino acid oxidase activity and accumulates free neutral D-amino acids in its tissues. In this study, D-aspartate oxidase activity and D-aspartate content in the tissues of these mutant mice were compared with those of normal mice. No significant difference was observed, indicating that the metabolism of acidic D-amino acids was unaffected in the mutant. |
| Keywords: | D-Amino acid oxidase D-aspartate oxidase D-aspartate mutant mouse |
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