| 磺胺醋酰合成技术研究 |
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| 引用本文： | 王淑月,张二巧,袁志法. 磺胺醋酰合成技术研究[J]. 河北科技大学学报, 2005, 26(2): 124-126,145 |
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| 作者姓名： | 王淑月 张二巧 袁志法 |
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| 作者单位： | 河北医科大学药物化学教研室,河北,石家庄,050017;河北医科大学药物化学教研室,河北,石家庄,050017;河北医科大学药物化学教研室,河北,石家庄,050017 |
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| 基金项目： | 河北省科技厅科技攻关课题(012761202) |
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| 摘 要： | 用相转移催化法合成磺胺醋酰,以TEBA(三乙基卞基氯化铵)为相转移催化剂,应用正交试验优化反应条件,考察了温度、相转移催化剂对反应的影响。收率由58.3%提高到71.67%,降低了成本,经改进纯制方法,减少了污染。
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| 关 键 词： | 磺胺醋酰 相转移催化 药物合成 |
| 文章编号： | 1008-1542(2005)02-0124-03 |
| 修稿时间： | 2004-07-12 |
Research of synthesizing technique for sodium sulfacetamide |
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| WANG Shu-yue,ZHANG Er-qiao and YUAN Zhi-fa. Research of synthesizing technique for sodium sulfacetamide[J]. Journal of Hebei University of Science and Technology, 2005, 26(2): 124-126,145 |
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| Authors: | WANG Shu-yue ZHANG Er-qiao YUAN Zhi-fa |
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| Affiliation: | Pharmacy College,Hebei Medical University,Shijiazhuang Hebei 050017,China;Pharmacy College,Hebei Medical University,Shijiazhuang Hebei 050017,China;Pharmacy College,Hebei Medical University,Shijiazhuang Hebei 050017,China |
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| Abstract: | The sodium sulfacetamide was synthesized by the method of mutually transfering catalysis. In order to optimize the reaction conditions, the method of orthogonal experiment was adopted and TEBA was used as mutual transfer catalyst. According to the experiment, the result shows that the temperature and the mutual transfer catalyst influences the chemical reaction dramatically. For one thing, the production of sodium sulfacetamide has increased from 58.3% to 71.6% while the cost of producing reduced. For another, after improving the way of purifying the products, pollution has decreased accordingly. |
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| Keywords: | sodium sulfacetamide thansfer mutually catalysis medicine synthesize |
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