| 江苏地区汉族人群六个短串联重复基因座的群体遗传学研究 |
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| 引用本文： | 易龙,应锋,等.江苏地区汉族人群六个短串联重复基因座的群体遗传学研究[J].南京大学学报(自然科学版),2001,37(5):653-658. |
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| 作者姓名： | 易龙 应锋 |
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| 作者单位： | 南京大学医学院DNA指纹实验室，南京大学医学院DNA指纹实验室，南京大学医学院DNA指纹实验室，南京大学医学院DNA指纹实验室，南京大学医学院DNA指纹实验室 南京，210093，南京，210093，南京，210093，南京，210093，南京，210093 |
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| 摘 要： | 采用复合扩增、聚丙烯酰胺凝胶电泳分型和银染显示的方法，对江苏地区汉族人群中111个无关个体的6个短串联联重复（STR）基因座（CSF1,TPOX，TH01，D16S539，D7S820和D13S317）进行了群体遗传学研究。经X^1检验。6个基因座的基因型频率符合Hardy-Weinberg平衡定律（P＞0．05）。它们的联合个体识别率（DP）值＞0．9999；联合非父排除率（PE）值＞0．9882。这6个基因座在江苏地区汉族人群中显示了高度的多态性和良好的鉴别能力，在法医学个人识别及亲子鉴定中有很高的应用价值。
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| 关 键 词： | 短串联重复基因座 群体遗传学 聚合酶链反应 法医学 江苏 汉族 个体识别 |
Population Genetic Studies on Six Short Tandem Repeat (STR) Loci in Han Population in Jiangsu Province, China |
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| Yi Long,Ying Feng,Ding Weidong,Wu Xiaoyu,Yao Genhong.Population Genetic Studies on Six Short Tandem Repeat (STR) Loci in Han Population in Jiangsu Province, China[J].Journal of Nanjing University: Nat Sci Ed,2001,37(5):653-658. |
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| Authors: | Yi Long Ying Feng Ding Weidong Wu Xiaoyu Yao Genhong |
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| Abstract: | Allele and genotype frequencies for six terameric short tandem repeat (STR) loci were established from 111 unrelated Han individuals in Jiangsu province, China using two multiplex polymerase chain reactions (PCR), followed by eletrophoresis of the PCR products in denaturing polyacrylamide gels and subsequent detection by silver staining. The loci were CSF1PO, TPOX, TH01, D16S539, D7S820 and D13S317. All loci met Hardy-Weinberg expectations ( P>0.05 ). The discrimination power (DP) and the power of exclusion (PE) from combination of 6 STR loci were >0.999 9 and >0.988 2, respectively. Hence, the six STR loci were highly suitable for forensic individualization and paternity tests to Han population in Jiangsu. |
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| Keywords: | short tandem repeat (STR) population genetic study polymerase chain reaction (PCR) forensic medicine |
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