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High-sensitive and temperature-self-calibrated tilted fiber grating biological sensing probe |
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| Authors: | Fu Liu Tuan Guo JianGuo Liu XiaoYang Zhu Yu Liu BaiOu Guan Jacques Albert |
| Affiliation: | 15724. Institute of Photonics Technology, Jinan University, Guangzhou, 510632, China 25724. Institute of Semiconductors, Chinese Academy of Sciences, Beijing, 100083, China 35724. Department of Biochemistry, Medical School, Jinan University, Guangzhou, 510632, China 45724. Department of Electronics, Carleton University, Ottawa, K1S 5B6, Canada |
| Abstract: | High sensitivity biological sample measurement has been achieved by using a 10° tilted fiber Bragg grating sensing probe. Human acute leukemia cells with different intracellular densities were clearly discriminated by identifying their slight refraction index (RI) perturbations in the range from 1.3342 to 1.3344, combining with a temperature self-calibration property. We studied the relationship between the intracellular density of cells (S50 and S60) and their RIs, the experimental results provide a potential way to verify the hypothesis for “density alteration in non-physiological cells (DANCE)”. |
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