| 强力霉素一侧关节腔注射对兔制动骨性关节炎模型对侧膝关节退变的影响 |
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| 引用本文： | 杨坚,史晨辉,董金波,王维山.强力霉素一侧关节腔注射对兔制动骨性关节炎模型对侧膝关节退变的影响[J].石河子大学学报,2010,28(3):344-348. |
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| 作者姓名： | 杨坚 史晨辉 董金波 王维山 |
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| 作者单位： | 石河子大学医学院第一附属医院,石河子,832008 |
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| 摘 要： | 为研究一侧关节腔内注射强力霉素对制动兔骨关节炎模型对侧膝关节早期退变的影响及作用机制。用36只新西兰大白兔随机分为空白对照组;模型对照4、8、12周组;给药8、12周组。模型组与给药组均给予石膏固定左下肢。石膏固定4周后,给药组每日给予1.33%的强力霉素0.3mL左膝关节腔内注射。分别在8周、12周处死动物,观察右膝指标包括:软骨大体形态、软骨mankin评分、软骨细胞MMP-3表达及滑膜细胞IL-1β表达。血液检测MMP-3及IL-1β含量。结果显示:与模型对照组比较,给药组软骨面光滑,mankin评分较低,IL-1β、MMP-3活性较低(P0.05)。与模型对照组比较,给药组血液中IL-1、MMP-3含量较低(P0.05)。由此可知,强力霉素一侧关节腔注射对制动兔骨关节炎模型对侧膝关节软骨早期退变有缓解作用,作用机制与抑制IL-1β、MMP-3的表达有关。
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| 关 键 词： | 骨关节炎 强力霉素 IL-1β |
The Effect of Intra-articular Injection with Doxycycline on the Early Degeneration of Opposite Knee of the Immobilizied Rabbit Model Osteoarthritis |
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| YANG Jian,ShI Chenhui,DONG Jinbo,WANG Weishan.The Effect of Intra-articular Injection with Doxycycline on the Early Degeneration of Opposite Knee of the Immobilizied Rabbit Model Osteoarthritis[J].Journal of Shihezi University(Natural Science),2010,28(3):344-348. |
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| Authors: | YANG Jian ShI Chenhui DONG Jinbo WANG Weishan |
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| Institution: | YANG Jian,ShI Chenhui,DONG Jinbo,WANG Weishan (College of Chemistry Chemi-engineering,Shihezi University,Shihezi 832000,China) |
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| Abstract: | To study the effect and action mechanism of intra-articular injection with doxycycline on the early degeneration of opposite knee of the braking rabbit model osteoarthritis.36 New Zealand rabbits were divided into 6 groups:blank control group,Model 4 week group,Model 8 week group,Model 12 week group,dministration 8 week group,administration 12 week group.Both Model group and administration group were given left lower extremity fixed by gypsum.After 4 weeks,the treatment group were intraarticularly injected ... |
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| Keywords: | MMP-3 |
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