Comparison between phylogeny of introns and exons in primate |
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Authors: | Ning Wang Runsheng Chen |
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Institution: | (1) Protein Engineering Lab, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China |
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Abstract: | Introns and exons of 7 genes (epsilon globin, gamma-1 globin, gamma-2 globin, delta globin, beta globin, Immunoglobulin andprepro-insulin) in primates have been separated out and used to infer phylogeny respectively. For each gene, results based on these two parts
have been compared and showed that: (i) the topology of introns is almost consistent with that of exons in each gene, while
the branch length of them varies, because of the dierent mutation rate; (ii) there is evidence that the substitution rate
of exons would decrease inhominoids, but that of introns would not; (iii) divergence time of orangutan deduced from different genes based on exons is various,
while that based on introns is much similar, and consistent with fossil records; (iv) there is a relationship between the
G + C content and the substitution rate. When the substitution rate of introns is higher than exons in a gene, the G + C content
of introns is less. The above results suggest that introns could provide useful evolutionary information among closety related
species. |
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Keywords: | phylogeny inference intron substitution rate molecular evolution |
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