|
|||||
|
|
| 毛冬青中三萜皂苷类化合物的NMR归属 | |
| 引用本文： | 张翠仙,杨金燕,林朝展,赵钟祥,冯育林,曾陇梅,祝晨蔯.毛冬青中三萜皂苷类化合物的NMR归属[J].中山大学学报(自然科学版),2009,48(1). |
| 作者姓名： | 张翠仙 杨金燕 林朝展 赵钟祥 冯育林 曾陇梅 祝晨蔯 |
| 作者单位： | 1. 广州中医药大学中药学院,广东,广州510006 2. 江西中医学院中药固体制剂制造技术国家工程研究中心,江西,南昌330006 3. 中山大学化学与化学工程学院,广东,广州510275 |
| 基金项目： | 国家中医药管理局重大科技专项资助项目，广东省中医药管理局基金，广州中医药大学创新基金 |
| 摘 要： | 从岭南地区习用药毛冬青Ilex pubescens Hook.Et.Arn根中分离得到2个三萜皂苷类化合物，经理化及波谱方法鉴定为ilexsaponin B1和ilexsaponin B2。首次利用2D NMR技术对此2个化合物的1 H和13C NMR数据进行了全归属。药理活性研究表明，毛冬青总皂苷具有明显降低血浆粘度的作用。 |
| 关 键 词： | 毛冬青Ilex pubescens Hook. Et.Arn. 三萜皂苷 NMR全归属 |
| 收稿时间： | 2008-07-10; |
NMR Assignment for Triterpenoids Saponins from the Root of Ilex pubescens |
|
| ZHANG Cuixian,YANG Jinyan,LIN Chaozhan,ZHAO Zhongxiang,FENG Yulin,ZENG Longmei,ZHU Chenchen.NMR Assignment for Triterpenoids Saponins from the Root of Ilex pubescens[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2009,48(1). | |
| Authors: | ZHANG Cuixian YANG Jinyan LIN Chaozhan ZHAO Zhongxiang FENG Yulin ZENG Longmei ZHU Chenchen |
| Institution: | (1.Guangzhou University of Chinese Medicine,School of Traditional Chinese Pharmacy, Guangzhou 510006,China; 2. Jiangxi University of Traditional Chinese Medicine, National Pharmaceutical Engineering Center (NPEC) for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006,China;3. School of Chemistry and Chemical Engineering, Sun Yat sen University, Guangzhou 510275,China) |
| Abstract: | Two pentacyclic ursane triterpenoids, ilexsaponin B1 1 and ilexsaponin B2 (2), were isolated from the root of Ilex pubescens, a traditional Chinese medicine used for the treatment of cardiovascular diseases. They were elucidated by chemical, physical methods and spectroscopic analysis. The NMR spectra data of compounds were recorded and firstly completely assigned by 2D NMR experiments, including 1 H-1 H COSY, HSBC and HSQC. Preliminary bioassays showed that the saponins from the root of Ilex pubescens exhibited potent degrading the plasma viscosity in rats. |
| Keywords: | Ilex pubescens triterpenoid saponins NMR assignments |
| 本文献已被 维普 万方数据 等数据库收录！ | |
| 点击此处可从《中山大学学报(自然科学版)》浏览原始摘要信息 | |
| 点击此处可从《中山大学学报(自然科学版)》下载免费的PDF全文 | |