Inhibition by tetanus and botulinum A toxin of the release of [3H]noradrenaline and [3H]GABA from rat brain homogenate |
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| Authors: | E Habermann |
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| Institution: | Buchheim-Institut für Pharmakologie der Justus-Liebig-Universit?t, Giessen, Federal Republic of Germany. |
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| Abstract: | Rat brain homogenate was preloaded with 3H]noradrenaline or 3H]GABA and stimulated with high K+. Tetanus toxin and botulinum A neurotoxin partially prevent the evoked 3H]noradrenaline release in the same range of toxin concentrations starting below 10(-10) M. In contrast, release of gamma-amino butyric acid (GABA) is much more sensitive to tetanus than to botulinum A toxin. |
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