双岐杆菌四联活菌联合柳氮磺吡啶治疗溃疡性结肠炎疗效观察

目的探讨双歧杆菌四联活菌联合柳氮磺吡啶治疗溃疡性结肠炎的疗效。方法2003—2008年90例溃疡性结肠炎随机分为治疗组及对照组，治疗组48例给予双歧杆菌四联活菌，两粒口服，3次／d，柳氮磺吡啶1．0，口服，4次／d；对照组42例给予柳氮磺吡啶1．0，口服，4次／d，两组患者治疗时间均为12周。结果治疗组及对照组临床症状改善有效率分别为81．2％、52．38％，肠道组织学炎症改善有效率分别为75％、52．3％。结论双歧杆菌四联活菌联合柳氮磺毗啶治疗溃疡性结肠炎的疗效好于单一柳氮磺吡啶治疗溃疡性结肠炎的疗效。

Effect of bifidobacterium tetravaccine tablets combined with Sulfasalazine on ulcerative colitis

Objective：To research the effect of bifidobacterium tetravaccine tablets combined with Sul- fasalazine on ulcerative colitis.Methods：90 patients with ulcerative colitis in our hospital from January 2003 to June 2008 were randomly divided into the experiment group and the control group. 48 patients in the experiment group were treated with bifidobacterium tetravaccine tablets combined with Sulfasalazine, 42 patients in control group were received only Sulfasalazine. The clinical symptom score and colon mucosa inflammation score were compared between two groups before treatment and 12 weeks after treatment. Re- stilts：The improvement rates of clinical symptom in experiment group and control group were 81.2% and 52.38% respectively. And the effective rates evaluated by colon mucosa inflammation score in experiment group and control group were 75% and 52.3% respectively. Conclusion：In the treatment of ulcerative coli- tis, combination of bifidobacterium tetravaeeine tablets and Sulfasalazine is more effective than Sulfasalazine.