基于变异系数的模糊物元模型评价阔叶十大功劳根不同提取部位的抗炎镇痛作用

为了筛选阔叶十大功劳根抗炎镇痛的有效部位,应用模糊物元模型对阔叶十大功劳根不同提取部位抗炎镇痛效果进行综合评价。采用醋酸扭体法、热水缩尾法及热板法,以小鼠足跖肿胀、耳廓肿胀程度考察阔叶十大功劳根不同提取部位的抗炎镇痛作用;用变异系数权重的模糊物元模型对其干预效果进行综合评价;通过计算贴近度比较模型组（M₁）、阳性对照组（M₂）、水提物组（M₃）、乙醇提取物组（M₄）、正丁醇提取物组（M₅）、乙酸乙酯提取物组（M₆）、石油醚提取物组（M₇）的抗炎镇痛效果。结果显示阔叶十大功劳根不同提取部位均有抗炎镇痛的效果,但各部位抗炎镇痛效果程度不同;反应不同部位抗炎镇痛总效应的贴近度值从大到小排序为M₆,M₄,M₃,M₅,M₂,M₇,M₁。基于变异系数权重的模糊物元模型可筛选出阔叶十大功劳根抗炎镇痛的最佳有效部位为乙酸乙酯提取部位,能够客观、科学地评价不同提取部位的抗炎镇痛效果。

The anti-inflammatory and analgesic effect of different extract parts from theroots of Mahonia bealei evaluated by fuzzy matter-element modelbased on the coefficient of variation

To screen the effective parts from the roots of Mahonia bealei for anti-inflammatory and analgesic, and explore the application of fuzzymatter-element model in the comprehensive evaluation of anti-inflammatory andanalgesic effects of different extract parts from the roots of Mahoniabealei. The acetic acid twisting method, the tail-immersion test, and thehot plate method were used, and the anti-inflammatory and analgesic effectswere investigated by mouse models of plantar swelling and auricle swelling. Thefuzzy matter-element model based on the weighting variation coefficient wasused for the evaluation of the comprehensive intervention effect. The nearnessdegree was calculated and compared among the model group (M₁),positive control group (M₂), water extract group (M₃),ethanol extract group(M₄), n-butanol extract group (M₅),ethyl acetate extract group (M₆), and petroleum ether extractgroup (M₇) for anti-inflammatory and analgesic effects. Thefindings showed that different extract parts from the roots of the Mahonia bealei have anti-inflammatoryand analgesic effects, but the degree varies. The values of nearness degree,defined for the anti-inflammatory and analgesic effects, were sorted from thelargest to the smallest: M₆, M₄, M₃, M₅, M₂, M₇, and M₁.The fuzzy matter-element model based on the weighting variation coefficient canbe used to screen the best effective extract part with ethyl acetate from rootsof the Mahonia bealei and evaluate the anti-inflammatory and analgesiceffects of the different extract parts from the roots of Mahonia bealei objectively and scientifically.