False interpretation of membrane transport data due to osmotic volume changes of cells |
| |
| Authors: | W Wilbrandt G F Fuhrmann |
| |
| Institution: | (1) Pharmakologisches Institut der Universität Bern, Friedbühlstrasse 49, CH-3008 Bern, Switzerland |
| |
| Abstract: | Summary It is shown theoretically that in a nonsaturable transport system across a cell membrane, the kinetical analysis yields (erroneously) apparent saturation kinetics if osmotic volume changes of the cell occur and are not taken into account. Experimentally this is illustrated for the case of exit of glycerol from beef erythrocytes. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
