Development in the research of molecular mechanism of Alzheimer’s disease |
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摘 要: | Alzheimer's disease (AD) is a kind of central nervous system disease. The cause of AD is unclear. It is found that the remarkable histopathological characters of AD are senile plaques and neurofibrillary tangles. β-amyloid plays an important role in the formation of senile plaques and the abnormal phosphorylation of Tau protein is the main reason of neurofibrillary tangles. Apolipoprotein E is correlated to AD' s access, and the third pathological character-AMY plaque perhaps represents a new cause of AD. Presenlin and proteinaceous infectious particles are also related with AD. A summary of molecular mechanism for AD and the development of research is presented.
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关 键 词: | Alzheimer's disease senile plaque neurofibrillary tangles β-amyloid Tau protein apoliporprotein E presenlin proteinaceous infectious particles. |
收稿时间: | 1998-09-08 |
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