Allogeneic effect on induction of thyroglobulin antibodies and thyroid lesions in mice

Summary All previous attempts failed to induce thyroglobulin antibodies or thyroid infiltrates in mice immunized with homologous thyroglobulin without adjuvants. However, an allogeneic effect obviated the need of adjuvants for triggering thyroglobulin-reactive lymphocytes to produce thyroglobulin antibodies or thyroid lesions.This work was supported by a grant from the Margaret Duffy and Robert Cameron C. Troup Fund. I thank Ellen Kenney for technical assistance and Dr Pei-nan Tsung for the X-ray irradiation.