质子泵抑制剂莱敏拉唑新衍生物的合成

以2—硝基—4—甲氧基苯胺和2—硝基—4—氯苯胺为原料．经氢气—雷尼镍还原后，再与乙氧基磺原酸钾进行环缩合反应得到2—巯基—5—甲氧基—1H—苯并咪唑．然后与含不同取代基的苄氯进行缩合反应，产物以过氧乙酸进行氧化，制得了10种莱敏拉唑衍生物．并通过红外、核磁共振和元素分析进行了结构确证．以上所有反应都具有操作简便、反应条件温和、产率较高等优点。

Synthesis of New Derivatives of Proton Pump Inhibitors Leminoprazole

4-Methoxy-2-nitroaniline and 4-chloro-2-nitroaniline were reduced and followed by cyclocondensation with potassium ethyl xanthate to give the 2-mercapto-5-methoxy-1H-benzimidazole which then reacted with different substituted benzyl chloride to produce ten new derivatives of Leminoprazole.Their structures have been identified by IR, ~1HNMR and elementary analysis.The remarkable advantages of the mentioned reactions above are mild, simple operation and good yields.