阿苯达唑药物制剂研究进展

阿苯达唑（ABZ）是一种苯并咪唑类衍生物，主要用作抗寄生虫药物，可用于治疗钩虫、蛔虫和鞭虫等线虫病，也可以治疗囊虫和包虫病. ABZ具有低溶解性以及体内广泛分布的特性，因此其在体内较难被吸收，生物利用度很低.近年来，为了提高ABZ的生物利用度与疗效，一系列的新型ABZ药物制剂被研发出来.文章综述了近20年来ABZ药物制剂的研究进展.

Research progress of albendazole medicinal preparations

Albendazole（ABZ） is a benzimidazole derivative which was mainly used as an antiparasitic drug to treat nematode diseases such as hookworm, roundworm, and trichuris, as well as cysticercosis and echinococcosis. Due to its low solubility and widespread distribution in vivo, ABZ is difficult to be absorbed in vivo and has low bioavailability. In recent years, in order to improve the bioavailability and efficacy of ABZ, a series of new ABZ formulations have been developed. This article reviews the research progress of ABZ medicinal preparations in the past two decades.