SKF83959调节大鼠的自发活动和焦虑行为

为了探讨多巴胺D1类受体激动剂SKF83959在动物自发活动、焦虑情绪和学习记忆方面的作用,将3月龄雄性大鼠随机分为给药组和空白对照组,分别腹腔注射1.0mg/kgSKF83959或等体积PBS缓冲液后,进行行为学测试.实验结果显示,与对照组相比,SKF83959注射后的大鼠在开放场测试中水平方向活动次数和总活动时间显著增加;在高架十字迷宫中给药组大鼠在闭臂区的停留时间更长,总穿臂次数和开臂、闭臂进臂次数也都减少.在恐惧性条件学习中,SKF83959处理组大鼠的记忆能力与对照组大鼠之间没有明显差异.结果提示,SKF83959能够提高大鼠的活动量,增加大鼠的焦虑情绪行为,而对大鼠恐惧记忆没有明显影响.

SKF83959 regulates locomotion activity and anxiety in rats

To investigate the effects of the selective agonist of dopamine D1-like receptors SKF83959 in locomotion activity, anxiety, and learning and memory，3 month old male rats were randomly divided into two groups：drug administrated group in which SKF83959 was injected (i.p. 1.0 mg/kg), and control group in which PBS buffer with equivalent volume was employed instead of SKF83959. Behavioral tests were then conducted. SKF83959 administration induced a significant increase in both total move times and total move time, as revealed by open field test. In elevated plus maze test, rats in drug administrated group exhibited much longer time staying in the close arms, with significant decreases in entries to total arms, the open arms and the close arms. However, fear conditioning test showed no difference in fear memory between drug administrated group and control group. The results indicate that SKF83959 can enhance the locomotion and anxiety. However, it does not affect the fear memory in rats.