热动力学研究Schiff碱钴配合物的抗菌活性

用微量热法测定了大肠杆菌及其在Co(Ⅲ)-SG配合物作用下的热谱曲线，计算了速率常数k，传代时间G、抑制、总产热量Q、单个细菌的产热量Qo和每分钟单个细菌的产热量Q0^-，建立了部分代谢参数之间的关系，探讨了大肠杆菌在不同温度和Co(Ⅲ)-SG作用下的代谢抑制，发现可用t、t1、t2和Qo定量表征在不同温度下大肠杆菌的生长代谢和药物的抗菌活性。

Thermokinetics Study on Antibacterial Activity of Schiff Base Co(Ⅲ) Complex

The power-time curves of E.coli reacting with Co(Ⅲ)-SG at different temperature has been determined by microcalorimtric method The multiplication rate constant k, generation time G,bacterial growth inhibition ratio I,total thermogenetic quantity Q, the heat quantity of a single bacterium Q0 and the heat quantity of a single bacterium per minute have also been calculated according to the power-time curves. On the basis of k～T data, the formula lnk～1/T has graphically obtained and been calculated.by graphing the parameters of E.coli growth metabolism, the relationships of tr～k,tg～k and t～k have been derived. The paper provides a discussion about the growth metabolism of E.coli reacted upon by Schiff base Co(Ⅲ) complex at different temperatures, and it is found that tr,tg,t and Q0 can be used to characterize bacterial growth metabolism and the antibacterial activity of drugs at different tmperature.