Irradiation of the head by 60Co opens the blood-brain barrier for drugs in rats |
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Authors: | S Bezek T Trnovec V Scasnár M Durisová M Kukan Z Kállay V Laginová V Svoboda |
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Institution: | Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia. |
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Abstract: | The passage of 6 model drugs; acetylsalicylic acid, chloramphenicol, ethimizol, carbisocaine, heptacaine, and diazepam, through the blood-brain barrier, was determined in unirradiated control rats and in animals 1, 3, and 7 days after irradiation of the head only with a dose of 25 Gy from a 60Co source. The brain uptake index (BUI), which compares the uptake of the test substance with that of 3H2O 5 s after their injection into the common carotid artery, was significantly increased in comparison with unirradiated controls 7 days after irradiation, for all substances tested except for ethimizol. For acetylsalicylic acid and chloramphenicol it was also significantly increased in the other time intervals. The less lipophilic substances showed a greater relative increase of BUI than the more lipophilic ones. |
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