Prianicin A and B,nor-sesterterpenoid peroxide antibiotics from red sea sponges |
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| Authors: | S Sokoloff S Halevy Varda Usieli A Colorni S Sarel |
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| Institution: | (1) Department of Pharmaceutical Chemistry, The Hebrew University School of Pharmacy, 91120 Jerusalem, (Israel);(2) Present address: Hebrew University Company on Research and Development; V.U. Institute for Standardization and Control of Pharmaceuticals, Ministry of Health, Jerusalem, Israel;(3) Marine Biology Laboratory, A.C. Hebrew University, Elat |
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| Abstract: | Summary The antibiotic properties of 2 acidic C24H40O4 nor-sesterterpenoid peroxides, prianicin A (1) and B (2), against gram-positive and gram-negative bacteria, and against fungi are herein described. They are 4–10 times more effective than tetracycline againstbeta hemolytic Streptococcus, but significantly non-effective against a variety of gram-negative bacteria.Acknowledgment. The authors are grateful to Prof. A. Kjaer of the Organic Chemistry Department of the Technical University of Denmark, for his help and fruitful discussions. |
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