有机小分子催化不对称环氧化

光学活性的环氧化合物是有机合成的重要原料.不对称环氧化反应可以使潜手性的烯烃转化为带有手性碳的环氧化合物,这个反应在医药、农药、香料等合成上具有重要的意义.有机小分子催化烯烃的不对称环氧化是一种高效,绿色的光学活性环氧化合物的合成方法,目前该类反应主要是通过手性酮和手性亚胺盐来催化实现的.文章介绍了该类反应的催化机理,并概述了这两类有机小分子催化的不对称环氧化反应的研究进展.

Catalytic Asymmetric Epoxidation of Organic Molecules

Optically active epoxy compound is an important intermediate for organic synthesis. Via asymmetric epoxidation reaction, prochiral olefin can convert into epoxy compound which having a chiral carbon. This reaction has important significance in medicine, pesticides, and synthetic fragrances. Small organic molecule catalyzed asymmetric epoxidation of olefins is an efficient and green synthesis of optically active epoxy compound, now the reaction is mainly use chiral ketones and chiral imide salt as effective catalyst. This article describes the catalytic mechanism of such reactions, and summarizesthe research progress in these two types of asymmetric epoxidation catalytic.