Hepatic phosphatidylcholine synthesis in deficiency of lysine and threonine: effect of malathion |
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Authors: | Y Singh V K Chaudhary S R Tyagi R Bhatnagar U K Misra |
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Institution: | (1) Department of Biochemistry, V.P. Chest Institute, University of Delhi, 110 007 Delhi, (India);(2) Present address: Division of Bacteriology, USAMRIID, Fort Detrick, 21701 Frederick, MD, USA |
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Abstract: | Summary Rats fed on a rice diet deficient in lysine and threonine showed increased activities of CDP-Choline pathway enzymes and incorporation of (methyl-3H)-choline into hepatic microsomal phosphatidylcholine, compared to rats fed on the same diet supplemented with lysine and threonine. However, the amount of microsomal phosphatidylcholine was significantly decreased in rats fed a deficient rice diet. These results suggest an enhanced phosphatidylcholine catabolism in rats fed on a rice diet deficient in lysine and threonine. Malathion administration reduced the amount of phosphatidylcholine in all the groups. |
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