水溶性头孢羟氨苄药物微粒超临界流体制备技术研究

以头孢羟氨苄-水+乙醇-二氧化碳系统为研究对象,利用超临界流体膨胀减压过程成功制备出了水溶性药物头孢羟氨苄的超细微粒,测定了混合器压力和温度、进液速率、溶液浓度对微粒形态、粒径和粒径分布的影响.实验结果表明:选用水+乙醇做溶剂,在适合的操作参数下可制备出粒径在1～3,μm适于吸入武给药的头孢羟氨苄超细微粒,且大部分微粒...

Study of preparation of water-soluble cefadroxil microparticles based on supercritical fluid technique

Cefadroxil(CD) microparticles were successfully prepared from CD-water+ethanol-CO2 mix-solution by the supercritical fluid expansion depressurization(SFED) process.The influences of the operation parameters,including the pressure and temperature in the mixing vessel,the feed solution rate and the solution concentration on the particle morphology,size and size distribution,were investigated.The experimental results show that CD microparticles with the diameter range of 1-3 μm which is suitable for inhalation delivery can be prepared by using water+ethanol as original solvent under some adapted operation conditions and most of them are well-defined spherical.Different parameters make different influences on the particle diameter and diameter distributions; the pressure in the mixing vessel is the most effective factor among these parameters.The particle characteristics can be controlled by adjusting operation conditions and the optimal operation parameters for preparing CD microparticles are as follows: The pressure is 14 MPa,temperature is 60 ℃,the solution concentration is 4 mg/mL and the feed solution rate is 3 mL/min.The particles with the minimum diameter and narrowest diameter distributions can be obtained under this condition.