纤维蛋白原三种测定方法的比较及临床应用评价

目的：对纤维蛋白原三种测定方法在出血、血栓疾病中的临床应用进行评价。方法：病人血浆用双缩脲法、凝血酶原时间法、凝血酶时间法测定纤维蛋白原含量，测定结果进行ｔ检验。结果：ＰＴ法Ｆｇ结果高于双缩脲法近一倍，ＴＴ法结果较双缩脲法略低。结论：不主张ＰＴ法测定血浆Ｆｇ含量，ＴＴ法简便、快速，反应血浆Ｆｇ活性水平，是出血、血栓性疾病的诊断、病情观察和疗效判定时Ｆｇ的一种较好的测定方法。

The comparison and evaluation of clinical application among three methods for measuring fibrino-gen in plasma

Objective: To evaluate the significance in clinical application through comparing three methods for measuring fibrinogen in plasma. Methods: The con- centration of fibrinogen in patients plasma were assayed using prothrombin time method (PT Method), thrombin time method(TT Method) and Dinret Method, then statistical analysis was performed with T-Test. Results: Concentration of fibrinogen in plasma with PT Method was about one times higher than Diuret Meth- od, the concentration of fibrinogen in plasma woth TT Method was lower slightly than that with Diuret Method. Conclusion: Assay of fibrinogen with PT Method is not recommended. TT Method is simple and rapid, besides, the measuring results reflect the activity of fibrinogen in plasma. We think TT Method should be a good laboratory test to be used in the clinical practice of hemorragic and thrombotic disease such as diagnosis, observation of patients condition and evaluation of therapeutioc effciency.