Prolactin and growth hormone releasing activity of [D-Met2, Pro5]-enkephalinamide in the rat after systemic administration |
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| Authors: | V Locatelli Daniela Cocchi S Bajusz S Spampinato E E Müller |
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| Institution: | (1) Department of Pharmacology, University of Milan, Milan, Italy;(2) Research Institute for Pharmaceutical Chemistry, Budapest, (Italy);(3) Institute of Pharmacology and Pharmacognosy, University of Catania, Cagliari, (Italy);(4) Institute of Pharmacology and Pharmacognosy, University of Cagliari, I-09100 Cagliari, (Italy) |
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| Abstract: | Summary The growth hormone (GH) and prolactin releasing (PRL) activity of D-Met2, Pro5]-enkephalinamide (EKNH2), an opioid peptide analog with higher opiate agonist activity that morphine, was compared in the unanesthetized male rat to those of equimolar doses of morphine upon systemic injection. EKNH2 proved to be a higher PRL, but not GH, releaser than the opiate alkaloid. |
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