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| Fabrication of Multi-layered Composite Scaffolds by Bi-directional Electrospinning Method | |
| 作者姓名： | 吴桐 黄晨 陈剑锋 刘威 莫秀梅 |
| 作者单位： | [1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering andBiotechnology , Donghua University, Shanghai 201620, China; [2]College of Textiles, Donghua University, Shanghai 201620, China; [3]College of Materials Science and Engineering, Donghua University, Shanghai 201620, China |
| 基金项目： | China，National Natural Science Foundations of China，Science and Technology Commission of Shanghai Municipality |
| 摘 要： | A multi-layered composite scaffolds consisting of poly （ L- ne） （ P （LLA-CL） ）, collagen （COL） and chitosan （CS） were fabricated by a bi-directional electrospinnlng method. Synthetic P （LLA-CL） was used as the middle layer to enhance the strength, while natural COL/CS blending （9： 1, v/v） was used as the bioactive surfaces （inner and outer layers ） to improve the biocompatibility. Each three transitional layers were set between inner/outer layer and middle layer for delamination resistance. Scanning electron microscopy （SEM） was used to observe the fiber morphology. The Fourier transform infrared attenuated total reflectance spectroscopy （FTIR-ATR） spectra, X- ray diffraction （XRD） and thermogravimetry （TG） tests were used to analyze the physical properties of the scaffolds. The results showed that the modified clectrospinning method bad no negative effect on the components, crystal structure and thermostability of the scaffolds, but could effectively combine the mechanical property of synthetic material and biocompatibility of natural materials. Such method could be applied to the fabrication of composite scaffolds for vascular, skin. and nerve tissue engineering. |
| 关 键 词： | electrospinning poly ( L.lactide-co-ε-caprolactone )( P(LLA-CL) ) collagen chitosan composite nanofibers |
Fabrication of Multi-layered Composite Scaffolds by Bi-directional Electrospinning Method |
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| WU Tong,HUANG Chen,CHEN Jian-feng,LIU Wei,MO Xiu-mei.Fabrication of Multi-layered Composite Scaffolds by Bi-directional Electrospinning Method[J].Journal of Donghua University,2014,31(5):625-629. | |
| Authors: | WU Tong HUANG Chen CHEN Jian-feng LIU Wei MO Xiu-mei |
| Institution: | 1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China 2. College of Textiles, Donghua University, Shanghai 201620, China 3. College of Materials Science and Engineering, Donghua University, Shanghai 201620, China 4. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China;College of Materials Science and Engineering, Donghua University, Shanghai 201620, China |
| Abstract: | |
| Keywords: | electrospinning poly (L-lactide-co-ε-caprolactone)(P(LLA-CL)) collagen chitosan composite nanofibers |
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