Biological activity of precocene analogues onLocusta migratoria |
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| Authors: | I Kiss A Fodor T Timar S Hosztafi P Sebok T Torok E Viragh M Berenyi |
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| Institution: | (1) Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, P.O.B. 521, H-6701 Szeged, (Hungary);(2) Alkaloida Chemical Company, H-4440 Tiszavasvari, (Hungary) |
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| Abstract: | Summary Structure-optimization studies of C-5-C-8-substituted precocene (P) analogues revealed that 1) compounds disubstituted asymmetrically at C-6, C-7 had an anti-allatal effect only if the C-6 side-group was shorter than that at C-7, 2) in the case of C-5, C-7 disubstitution, activity was enhanced by Me at C-5 whereas MeO caused inactivity. Effects of various other substitutions are also discussed. |
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| Keywords: | Precocene structure-activity relationship effect of C-5-C-8 substitution and their combination Locusta migratoria |
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