猕猴进行遥测系统植入子植入手术的经验体会

目的 探讨猕猴应用遥测技术进行植入子在植入手术围手术期内遇到的各类状况以及处理措施。 方法 对 本机构 8 例猕猴的植入子植入手术过程中出现的问题进行归类、分析和总结。 对出现的术前麻醉与备皮、给药困 难,术中出血量、麻醉程度,术后切口淤肿、动物自主破坏缝线或植入子导线等问题分析产生原因,提出预防或解决 方法并予以实施,通过手术前后体质量、体温、血常规、生化指标的检测结果确认无感染或炎症等不良预后,通过检 测术后心血管系统各指标并与猴白昼基础值进行比较确认术后生理状态良好。 结果 通过标准化的手术过程与 完善的应对异常的预案,成功实施了植入子植入手术,手术成功进行并且术后恢复良好,受术猴的体质量、血常规、 生化、心电、呼吸、血压、体温等指标显示手术前后基本无差别。 结论 通过猕猴遥测系统植入子植入手术实例,成 功实施猴应用遥测系统的手术流程,提高了遥测动物模型建模的成功率,对国内机构使用植入式遥测系统建立大 动物模型在安全药理学研究的应用中起到一定的借鉴作用。

Experience in the Implementation of Telemetry System Implant Surgery in Rhesus Monkeys

Objective To investigate the various conditions and treatment measures encountered in the perioperative period of implanted implants by using telemetry technology. Method The problems occurred in the implantation of 8 cases of macaques in this institution were classified, analyzed and summarized. Analyze the causes of preoperative anesthesia and skin preparation, difficulty in administration, intraoperative blood loss, anesthesia degree, postoperative incision and bruise, animal self-destructive suture or implanted lead wire, and propose prevention or solution. To be implemented, the prognosis of no infection or inflammation was confirmed by the result of weight, body temperature, blood routine and biochemical indicators before and after surgery, and by examining the postoperative cardiovascular system indicators and comparing with the basic values of the monkey in daytime, it was confirmed that the postoperative physiological state was good. Result Through the standardized surgical procedure and the perfect plan for coping with abnormalities, the implant implantation was successfully performed. The operation was successful and the postoperative recovery was good. The monkey’ s weight, blood routine, biochemistry, electrocardiogram, respiration, blood pressure, indicators such as body temperature showed no difference before and after surgery. Conclusion The surgical procedure of monkey application telemetry system is successfully established, and the success rate of telemetry animal model modeling is improved. It can be used as a reference for the application of domestic monkey telemetry model in safety pharmacology research.