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Colcemid effects on homologue pairing and crossing over during fetal mouse oogenesis |
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| Authors: | G Jagiello W K Sung J -S Fang M B Ducayen |
| Institution: | (1) Departments of Obstetrics and Gynecology, Human Genetics and Development, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, 10032 New York, New York, USA;(2) Center for Reproductive Sciences of the International Institute for the Study of Human Reproduction, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, 10032 New York, New York, USA |
| Abstract: | Summary Colcemid was administered to gestational day 13 female mice to test effects on homologue pairing, synapsis and recombination of fetal oogenesis. Pairing abnormalities were detected in pachytene oocytes by light and electron microscopy examination of bivalents and synaptonemal complexes. Reduction of total chiasmata per treated diplotene oocyte (22.74) compared to controls (31.07) was found. |
| Keywords: | Colcemid meiosis recombination oogenesis nondisjunction |
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