Effect of prostaglandin E2 (PgE2) on the biosynthesis and metabolism of noradrenaline (NA) in the isolated and perfused rabbit heart]

In isolated perfused rabbit heart, Pg E2 at concentrations ranging from 1.10(-8) to 1.10(-4) M has shown no significant action either on the biosynthesis or on the metabolism of NA. But it inhibited NA uptake, nevertheless this action was weak.