广州地区早孕妇女HCMV感染及其垂直传播

用聚合酶链反应技术检测１１０例早孕妇女尿液及其胚胎绒毛的ＨＣＭＶＤＮＡ。结果孕母尿液与胚胎绒毛的ＨＣＭＶＤＮＡ阳性率分别为１５．５％和７．３％，宫内感染率为４１．２％，孕母尿液与胚胎绒毛的ＨＣＭＶ阳性数密切相关，提示孕母尿路排毒系全身性活动性感染；孕母尿液ＨＣＭＶ阳性与阴性者其胚胎绒毛ＨＣＭＶ阳性数具显著差异，表明孕母尿液阳性者较阴性者处于垂感染胚胎的高危状态，建立采用ＰＣＲ法普查早孕妇女尿液ＨＣ

A Preliminary Study of Human Cytomegalovirus Infection from Early Pregnant Women to Their Embryos in Guangzhou Area

A total number of 110 cases of early pregnant women' s urine specinens and their embryos'chorionic Villous samples(CVS)were screened for HCMV DNA by polymerase chain reation .Therates of positivity for the mother's urine specimens and for their embryos's CVs were 15.5%(17/110)and 7.3%(8/110)aspectively.Thus the rate of positive HCMV intrauterine infectionamong the positive mothers was 41.2%. Statistic analysis showed that among early pregnantwomen the intiauterine infforon was closely correlated with the positive urine specirnens for HCMV(P<0.01).This suggested that excreling HCMV in the urine nught be an indication of genelalactlve infection of the mother.The difference of HCMV positve embcyos'CVS between whosemothers urihe were also positive and those their urine were negetive was statistically significant(P<0.01).These results revealed that the embryo is at high risk of HCMV intrauterineinfection when his mother has had a general active infection.It was suggested that theurine specimens of all pregnant women should be screened,HCMV by PCR if possible.