锰对大鼠子代不同时期血液中必需微量元素的影响

研究锰对大鼠子代不同时期血液中必需微量元素的影响。将妊娠大鼠随机分为4组，腹腔内注射氯化锰，剂量分别为0，7．5，15，30mg/kg，待其自然分娩后采用原子吸收光谱法测定其子代新生鼠及20日龄鼠血液中微量元素锰、铜和锌含量。实验各组新生鼠血液中锰含量高于对照组（P＜0．01），而各组20日龄仔鼠血液中锰含量差异无显著性（P＞0．05）；各实验组新生鼠和20日龄鼠血液中锌含量均明显降低（P＜0．05，P＜0．01）；实验各组新生鼠及20日龄鼠血液中铜含量与对照组差异的无显著性（P＞0．05）。研究表明，大鼠孕期染锰使其新生鼠及20日龄仔鼠血液中锰、锌等的含量发生变化，影响了锰、锌在体内的代谢，对其生长发育产生不利影响。

Effects of Manganese on Essential Microelements in the Blood of Filial Rats in Different Periods

To study the effects of manganese on the essential microelements in the blood of filial rats in different periods after mother-rats were exposed by manganese,impregnated female rats were injected intraab dominally with 0,7.5,15,30mg/kg MnCl2 for 8 times every other day, and the contents of Mn,Cu and Zn in the blood of newborn rats and 20 d ay old rats were determined with atomic absorption spectroscopy.The contents of Mn in the blood of new born rats of three experimental groups have significantly increased compared with the control group( P <0.01)while the contents of Mn were not significantly different in the blood of 20 day old rats among four groups (P >0.05).The levels of Zn in the blood of new born rats and 20 day old rats of three experimental groups were lower than those of the control groups( P<0.05,P <0.01). The levels of Cu demonstrated no significant difference among four groups( P >0.05).After impregnated female rats were exposed to manganese,their filial rats' metabolism of Mn and Zn in the blood were influenced. Their filial rats' growth and development could be harmed.