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Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer |
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| Authors: | Gudmundsson Julius Sulem Patrick Rafnar Thorunn Bergthorsson Jon T Manolescu Andrei Gudbjartsson Daniel Agnarsson Bjarni A Sigurdsson Asgeir Benediktsdottir Kristrun R Blondal Thorarinn Jakobsdottir Margret Stacey Simon N Kostic Jelena Kristinsson Kari T Birgisdottir Birgitta Ghosh Shyamali Magnusdottir Droplaug N Thorlacius Steinunn Thorleifsson Gudmar Zheng S Lilly Sun Jielin Chang Bao-Li Elmore J Bradford Breyer Joan P McReynolds Kate M Bradley Kevin M Yaspan Brian L Wiklund Fredrik Stattin Par Lindström Sara Adami Hans-Olov McDonnell Shannon K Schaid Daniel J Cunningham Julie M Wang Liang |
| Institution: | deCODE genetics, 101 Reykjavik, Iceland. julius@decode.is |
| Abstract: | We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease. |
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