Increase of interferon antiviral activity by exogenous cyclic adenosine-3′∶5′-monophosphate (cAMP) |
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| Authors: | H Koblet R Wyler U Kohler |
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| Institution: | (1) Institute of Medical Microbiology, University of Berne, Friedbühlstrasse 51, CH-3008 Berne;(2) Institute of Virology, University of Zurich, Winterthurer Strasse 266A, CH-8057 Zürich, (Switzerland);(3) Present address: Institute of Medical Microbiology, University of Berne, Switzerland;(4) Present address: Institute of Virology, University of Zürich, Switzerland |
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| Abstract: | Summary Some effects of cAMP on replication of Semliki Forest Virus in chick embryo fibroblast cell cultures are described. Depending on concentration, the incorporation of 3H]-uridine into viral RNA or the formation of plaqueforming units is inhibited; the highest concentration tested was 8 mM. Cyclic AMP has an effect of its own and increases the Interferon action in the lower concentration ranges of Interferon (up to 1 unit/ml). The effect of cyclic AMP is fast, needs no induction and is also visible in late phases of viral replication. However, these experiments do not establish a causal relation between cAMP and Interferon.Work supported by the Swiss National Science Foundation, grants 3.1050 and 3.540. |
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