<Emphasis Type="Italic">Dictyostelium</Emphasis> dynamin B modulates cytoskeletal structures and membranous organelles |
| |
Authors: | Amrita?Rai Heike?N?the Nikolay?Tzvetkov Elena?Korenbaum Email author" target="_blank">Dietmar?J?Manstein |
| |
Institution: | 1.Hannover Medical School,Hannover,Germany;2.Institut für Biophysikalische Chemie, OE 4350, Medizinische Hochschule Hannover,Hannover,Germany;3.Max-Planck-Institut für Medizinische Forschung,Heidelberg,Germany;4.Forschungseinrichtung für Strukturanalyse, OE 8830, Medizinische Hochschule Hannover,Hannover,Germany |
| |
Abstract: | Dictyostelium discoideum cells produce five dynamin family proteins. Here, we show that dynamin B is the only member of this group of proteins that
is initially produced as a preprotein and requires processing by mitochondrial proteases for formation of the mature protein.
Our results show that dynamin B-depletion affects many aspects of cell motility, cell-cell and cell-surface adhesion, resistance
to osmotic shock, and fatty acid metabolism. The mature form of dynamin B mediates a wide range and unique combination of
functions. Dynamin B affects events at the plasma membrane, peroxisomes, the contractile vacuole system, components of the
actin-based cytoskeleton, and cell adhesion sites. The modulating effect of dynamin B on the activity of the contractile vacuole
system is unique for the Dictyostelium system. Other functions displayed by dynamin B are commonly associated with either classical dynamins or dynamin-related
proteins. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|