Circadian variation of the streptozotocin-diabetogenic effect in mice

Summary Streptozotocin was injected in normal mice every 4h, during the day. Greatest number of diabetic animals were obtained at 16.00 h (95%) and lowest at 08.00 h (50%). Magnitude of hyperglycemia also showed similar distribution. This effect might be considered when planning its use for both experimental and clinical purposes.This work was done with funds provided by Conicet, Secyt and Cediquifa.Thanks are due to Dr W. E. Dulin for kindly provision of SZ and Mrs E. E. Gagliardino for technical assistance.