Hypothalamic histamine modulates adaptive behavior of rats at high environmental temperature |
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| Authors: | K Fujimoto T Sakata K Ookuma M Kurokawa A Yamatodani H Wada |
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| Institution: | (1) Department of Internal Medicine I, Faculty of Medicine, Kyushu University, 812 Fukuoka, Japan;(2) Department of Pharmacology II, Faculty of Medicine, Osaka University, 530 Osaka, Japan |
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| Abstract: | Summary Histamine content in the rat hypothalamus was lower at 4°C and higher at 31°C compared to that at 21°C. Pretreatment with  -fluoromethylhistidine, a  suicide inhibitor of histidine decarboxylase, attenuated both the increased level of hypothalamic histamine and rat adaptive behavior at 31°C. Increase of histamine content in the hypothalamus appears to be an important factor contributing to rat adaptive behavior to high environmental temperature. |
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| Keywords: | Histamine hypothalamus environmental temperature adaptive behavior |
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