Granulocytosis induced in vivo by a mouse marrow stromal cell line,BMA1, which produces colony stimulating factor |
| |
| Authors: | K Fujita Y Shimomura J Fujita K J Mori |
| |
| Institution: | (1) Department of Orthopedic Surgery, National Defence Medical College, 359 Saitama, (Japan);(2) Department of Microbiology, Faculty of Medicine, Kyoto University, 606 Kyoto, (Japan) |
| |
| Abstract: | Summary Nude mice were inoculated with BMA1 cells. These are cells which produce granulocyte-macrophage colony stimulating factor (GM-CSF); They are derived from mouse bone marrow stromal cells transfected with adenovirus 5 DNA. Progressive neutrophilia developed as the tumor grew, but disappeared quickly after local tumor excision. Media conditioned with tumor cells had GM-CSF but neither erythropoietin, nor burst-promoting activity. In all the tumors which developed, focal areas of bone formation were found among fibrosarcomatous tissues. |
| |
| Keywords: | BMA1 cell line colony stimulating factor bone marrow stromal cell bone formation |
| 本文献已被 SpringerLink 等数据库收录！ |
|
